2 edition of effect of drugs on the biochemical and biophysical properties of mucus. found in the catalog.
effect of drugs on the biochemical and biophysical properties of mucus.
Ann S. Readman
Thesis (Ph.D) - CNAA, Brighton Polytechnic.
|Contributions||Brighton Polytechnic. Department of Pharmacy.|
MIT associate professor of biological engineering Katharina Ribbeck studies mucus — a substance with a high ick factor, but one of the most important defenses our bodies have against infection. Mucus performs many critical physiological functions, and by learning about it, Ribbeck hopes to devise new ways to diagnose and treat disease. An integral arm of our research is to better understand how the human body prevents infections by harmful microbes on mucosal surfaces. Mucus is one major ecological niche for the human microbiota – it accommodates trillions of microbes where densities approach 10 11 –10 12 cells/mL, a record for any microbial ecosystem documented so far. Many of these microbes are important for our health.
To study the protective function of the cervical mucus in preterm birth we performed a pilot case-control study to measure the viscoelasticity and permeability properties of mucus obtained from pregnant women at high-risk and low-risk for preterm birth. cervical mucus has altered biophysical and biochemical properties, allowing for. Trefoil peptides have been implicated in non-covalent binding to muc37,38 and appear to be capable of altering the biophysical and protective properties of the mucus .
Sniffing, sneezing, coughing—from allergies to the common cold, too much mucus can cause misery. Yet, the ability to get mucus up and out is critical to its function. In patients with cystic fibrosis (CF) or other lung diseases, airway mucus can be highly elastic and much more difficult to clear, leading to airflow obstruction and lung infection. Now, Yuan et al. find that the biophysical. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers or health and adiposity. Lipids Health Dis ; View.
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Eur J Respir Dis Suppl. ; (Pt 2) The effect of some drugs on the biophysical and biochemical properties of pig tracheal by: 4. Effect of S-Carboxymethylcysteine on the Biophysical and Biochemical Properties of Mucus in Chronic BronchiticsCited by: 5.
Effect of S-carboxymethylcysteine on the biophysical and biochemical properties of mucus in chronic bronchitics.
Cox A, Jabbal-Gill I, Marriott C, Davis SS. PMID:Cited by: 5. Altered mucus biophysical properties and weakened innate defense mechanisms ensue, furthering the progression of the disease. Mucins, the high‐molecular‐weight glycoproteins responsible for the viscoelastic properties of the mucus, play a key role in the disease but the actual mechanism of mucus accumulation is still by: 1.
Mucus was collected daily from open-ended pouches established surgically in three mini-pigs. After a five day control period bromhexine hydrochloride (BHCl) was administered to each pig at dose levels ofand -1 twice daily for five days. Each study period was followed by a five day washout period, when mucus was collected but no drug given.
The viscoelastic properties of each. Nevertheless, mucoactive drugs such N-acetylcysteine that are also, or perhaps primarily, antioxidants have some beneficial effects in inflammatory airway disease. Reactive oxygen and nitrogen species are potent stimulants of mucus secretion.
Consequently, antioxidants and inhibitors of inducible nitric oxide synthase may have clinical benefit for airway mucus hypersecretion. After drug carrier particles reach the mucus layer, a corona is formed on the surface of the particles, depending on the surface properties of the particles.
Here, in particular, mucoglycoproteins-mucins are the key macromolecules responsible for the structural properties of mucus and they determine its function as a molecular sieve , .
Critically, MPPs allow enhanced drug and gene delivery to mucosal tissues without diminishing the protective function of mucus. Recent progress in the development of MPPs as a biophysical tool to probe the length-scale dependent rheological properties of mucosal secretions and as a method for drug and gene delivery is highlighted.
Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications.
The present study aims to better understand the topical toxicity induced by DCF using membrane models that mimic the physiological, biophysical, and chemical environments of GI mucosa segments.
Biochemical mechanisms that are adapted to counter the effect of antimicrobial drugs by resistant pathogens in (A) tetracyclines (B) aminoglycosides and B-lactams, and (C) FQ and RMP. (A) Failure of penetration into the target cells.
(B) Inactivation of the drug by enzymatic attack. (C) Alteration of the drug target within the cell. Finally, mucus expression and composition is altered in cancers of epithelial origin [52 ••].
Mucus and pharmacology. Mucus is the first barrier with which nutrients and enteric drugs must interact and diffuse through, in order to be absorbed and gain access.
We will also discuss how mucus biology is perturbed in disease and how insights regarding the biochemical and biophysical characteristics of mucus and sputum need to be considered to more effectively treat airway obstruction in chronic inflammatory airway diseases.
Mucin Biology. The mucin protein backbones are encoded by genes called MUCs. In particular, our research works to understand the biochemical and biophysical properties of mucin biopolymers, which give airway mucus its characteristic gel-like properties, and how they are altered in diseases such as Asthma, COPD, and cystic fibrosis.
Nguyen, Juliane WEBSITE EMAIL PUBLICATIONS: PHD PROGRAM Pharmaceutical Sciences. RESEARCH. been used to improve airway clearance by altering mucus biophysical properties. Recommending and administering medications for air-way clearance therapy are within the respiratory thera-pist’s scope of practice.
Therapy should be matched to the patient’s disease and therapy goals. The potential harmful. Biophysical Properties of Mucus The Mucociliary Clearance Consortium consists of 9 research groups in five states and England. The Mucociliary Clearance Consortium is a research program funded by the Cystic Fibrosis Foundation to cre-ate a community of researchers investigating key aspects of mucus biology, biophysics and clearance.
Using confocalimaging, rheology, and biochemical measures of inflammation and oxidation, wefound that CF airway mucus gels have a molecular architecture characterized by a core of mucin covered by a web of DNA and a rheological profile characterized by high elasticity that can be normalized by chemical reduction.
Note: This document contains side effect information about sulfamethoxazole / trimethoprim. Some of the dosage forms listed on this page may not apply to the brand name Bactrim. For the Consumer. Applies to sulfamethoxazole / trimethoprim: oral suspension, oral tablet.
Other dosage forms: intravenous solution; Side effects requiring immediate medical attention. Side Effects & Safety When taken by mouth: When taken in small quantities, such as a flavoring for foods, black seed is LIKELY SAFE for most people. Black seed oil and black seed powder are.
In particular, our research works to understand the biochemical and biophysical properties of mucin biopolymers, which give airway mucus its characteristic gel-like properties, and how they are altered in diseases such as Asthma, COPD, and cystic fibrosis. Dickerson, Brad EMAIL PUBLICATIONS: PHD PROGRAM Biology.
RESEARCH INTEREST. Microsomes, Drug Oxidations, and Chemical Carcinogenesis, Volume I, documents the proceedings of the 4th International Symposium on Microsomes and Drug Oxidations held in Ann Arbor, July The symposium reviewed progress in the understanding of scientific and biomedical problems from a biochemical, biophysical, pharmacological, and.
Due to its importance in the pharmaceutical industry, ligand dynamic simulations have experienced a great expansion. Using all-atom models and cutting-edge hardware, one can perform nonbiased ligand migration, active site search, and binding studies.
In this Letter, we demonstrate (and validate by PCR mutagenesis) how these techniques, when combined with quantum mechanics, open new. Mucus is characterized by multiple levels of assembly at different length scales which result in a unique set of rheological (flow) and mechanical properties.
These physical properties .The endogenous mucus secreted by the tissue, in vitro, was shown to have a significant effect on the rate of drug transfer with removal of this layer resulting in rate increases of between 60 and.